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Similac Total Comfort Powder Infant Formula

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Has partially hydrolyzed protein for easy digestion
For mild tolerance symptoms such as fussiness and gas due to lactose sensitivity
With OptiGRO, an exclusive blend of DHA, lutein and vitamin E

Similac Total Comfort Powder Infant Formula

Select Option	12.6 oz - 1 Each 12.6 oz - Case of 6 Clear

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First Delivery: March 10, 2026 - March 11, 2026

Save 10% now on 1st Autoship*, 5% on repeat orders

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(10% off first Autoship order*)

Price range: $26.25 through $157.00

Has partially hydrolyzed protein for easy digestion
For mild tolerance symptoms such as fussiness and gas due to lactose sensitivity
With OptiGRO, an exclusive blend of DHA, lutein and vitamin E

Gentle on Tiny Tummies
Made with partially broken-down whey protein for easier digestion and comfort.

Supports Digestive Wellness
Includes prebiotics that promote the growth of beneficial gut bacteria.

Brain & Eye Development
Enriched with DHA and lutein—nutrients also found in breast milk.

Better Calcium Absorption
Formulated without palm olein oil to help improve calcium uptake.

Trusted by Hospitals
Similac is the #1 infant formula brand used in hospitals across the U.S.

1. What makes Similac Total Comfort different from other formulas?
Similac Total Comfort is specially designed with partially broken-down protein for easier digestion, making it ideal for babies with sensitive tummies.

2. Is Similac Total Comfort safe for newborns?
Yes, it is suitable for newborns and can be used as a complete source of nutrition from birth.

3. Does it help with gas or fussiness?
Many parents find that this gentle formula helps reduce fussiness, gas, or mild spit-up due to its easy-to-digest protein.

4. Is Similac Total Comfort non-GMO?
Yes, the formula is made with ingredients that are not genetically engineered (non-GMO).

Ingredients

Corn Maltodextrin, Whey Protein Hydrolysate, High Oleic Safflower Oil, Sugar, Soy Oil, Coconut Oil. Less than 2% of: Schizochytrium Sp. Oil*, M. Alpina Oil†, Short-chain Fructooligosaccharides, Beta-Carotene, Lutein, Calcium Citrate, Potassium Phosphate, Calcium Phosphate, Potassium Hydroxide, Salt, Magnesium Chloride, Ascorbic Acid, Choline Chloride, Inositol, Potassium Chloride, Sodium Citrate, Calcium Hydroxide, Potassium Citrate, Ferrous Sulfate, Taurine, Choline Bitartrate, Zinc Sulfate, Ascorbyl Palmitate, L-Carnitine, Niacinamide, Mixed Tocopherols, d-Alpha-Tocopheryl Acetate, Calcium Pantothenate, Copper Sulfate, Vitamin A Palmitate, Thiamine Hydrochloride, Riboflavin, Pyridoxine Hydrochloride, Folic Acid, Manganese Sulfate, Potassium Iodide, Phylloquinone, Biotin, Sodium Selenate, Vitamin D3, Vitamin B12, and Nucleotides (Adenosine 5′-Monophosphate, Cytidine 5′-Monophosphate, Disodium Guanosine 5′-Monophosphate, Disodium Uridine 5′-Monophosphate). Contains milk ingredients.