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Can be taken at the first sign of a UTI
Slows down bacterial growth
Provides general pain relief
Dual action formula

AZO Urinary Tract Defense Tablets

Size	24 tablets - 1 Each Clear

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First Delivery: March 11, 2026 - March 12, 2026

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(10% off first Autoship order*)

$16.80

Can be taken at the first sign of a UTI
Slows down bacterial growth
Provides general pain relief
Dual action formula

About AZO Urinary Tract Defense Tablets

AZO Urinary Tract Defense helps control your urinary tract infection and relieve pain until you see a doctor. It includes Methenamine, the #1 OTC drug ingredient for UTI bacteria control.

Key Benefits & Features

Helps control your urinary tract infection until you see a doctor
Contains methenamine, a powerful anti-bacterial medicine that works by slowing down the growth of the bacteria along the urinary tract and helping to control your UTI
Contains methenamine, the only antibacterial UTI ingredient available without a prescription, and sodium salicylate for general pain relief
Remember, only a doctor can prescribe the antibiotics needed to fully treat your UTI

AZO Urinary Tract Defense Tablets FAQs

What causes UTIs (urinary tract infections)?

Bacteria entering the urinary tract system and attaching to the bladder wall typically cause urinary tract infections. The most common bacteria to cause a UTI is E.coli.

What are the signs and symptoms of a UTI?

The most common UTI symptoms are: – Pain or painful urination – Frequent need to urinate – Burning sensation while urinating – Bladder spasm – Lower back pain – Fever If you experience any of these symptoms, immediately consult your physician. Learn more about common UTI symptoms and about diagnosing a UTI.

Will AZO Urinary Tract Defense cure my UTI?

No. The only clinically proven cure for a UTI is a prescription antibiotic. AZO Urinary Tract Defense will only help inhibit the progression of infection until you see a healthcare professional. AZO is not intended to replace medical care.

What is the difference between AZO Urinary Tract Defense and AZO Urinary Pain Relief?

AZO Urinary Tract Defense and AZO Urinary Pain Relief contain different active ingredients that provide different UTI relief benefits. AZO Urinary Tract Defense contains methenamine to help control the infection until you can seek medical treatment and sodium salicylate to provide general pain relief. AZO Urinary Pain Relief contains phenazopyridine hydrochloride which provides fast, targeted relief for pain, burning and urgency associated with a UTI.

Will AZO Urinary Tract Defense interfere with prescription medications?

Please consult your doctor if you are taking any other prescription medications before taking AZO Urinary Tract Defense. AZO Urinary Tract Defense should not be taken with sulfonamide drugs. Products that decrease the acidity of the urine (such as antacids, sodium bicarbonate, potassium or sodium citrate, carbonic anhydrase inhibitors such as acetazolamide) may reduce the effectiveness of AZO Urinary Tract Defense. AZO Urinary Tract Defense should not be taken with anticoagulants, steroid drugs, or in addition to other non-steroidal anti-inflammatory drugs (aspirin, ibuprofen, naproxen and others).